Yay!!! Our first manuscript was accepted after a re-tool and re-pitch necessitated by finding out I was wrong about us being "first."
1) READ the literature even MORE than you thought you have.
2) Be very flattering, polite and conciliatory in responses to reviewers even when you are not doing precisely what they wanted you to do in the revision (such as not performing a whole new set of control experiments that would only minimally add to the confidence in the result, and instead just thanking them very much for their insight and modifying the text to emphasize the controls you DID do).
Noody flipper dipper
2 days ago